{
  "desc": "Evidencia científica con DOI verificado. Cada doi resuelve en Crossref.",
  "generated_from": [
    "site/src/content/vitamins",
    "site/src/content/diets",
    "site/src/content/conditions",
    "site/src/content/substances"
  ],
  "entries_with_studies": 38,
  "entries_by_kind": {
    "vitamin": 13,
    "diet": 5,
    "substance": 20
  },
  "studies_with_doi": 48,
  "studies_without_doi": 14,
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    {
      "kind": "diet",
      "id": "low-carb-keto",
      "name": "Dieta baja en carbohidratos / Cetogénica",
      "studies": [
        {
          "title": "The Effect of Low-Fat and Low-Carbohydrate Diets on Weight Loss in Adults: A Systematic Review and Meta-Analysis",
          "source": "Nutrients",
          "year": 2020,
          "doi": "10.3390/nu12123774",
          "pmid": "33317019",
          "url": "https://doi.org/10.3390/nu12123774"
        }
      ],
      "verified_count": 1
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    {
      "kind": "diet",
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      "name": "Dieta baja en FODMAPs",
      "studies": [
        {
          "title": "Efficacy of a low FODMAP diet in irritable bowel syndrome: systematic review and network meta-analysis",
          "source": "Gut",
          "year": 2021,
          "doi": "10.1136/gutjnl-2021-325214",
          "pmid": "34376515",
          "url": "https://doi.org/10.1136/gutjnl-2021-325214"
        }
      ],
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    {
      "kind": "diet",
      "id": "dash",
      "name": "Dieta DASH",
      "studies": [
        {
          "title": "Dietary Approaches to Stop Hypertension (DASH) Diet and Blood Pressure: A Systematic Review and Meta-Analysis",
          "source": "Advances in Nutrition",
          "year": 2020,
          "doi": "10.1093/advances/nmaa041",
          "pmid": "32330233",
          "url": "https://doi.org/10.1093/advances/nmaa041"
        }
      ],
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      "kind": "diet",
      "id": "mediterranean",
      "name": "Dieta Mediterránea",
      "studies": [
        {
          "title": "The role of the Mediterranean diet in reducing the risk of cardiovascular disease and cancer: a systematic review and meta-analysis",
          "source": "GeroScience",
          "year": 2025,
          "doi": "10.1007/s11357-024-01488-3",
          "pmid": "39797935",
          "url": "https://doi.org/10.1007/s11357-024-01488-3"
        }
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    {
      "kind": "diet",
      "id": "vegan",
      "name": "Dieta Vegana",
      "studies": [
        {
          "title": "Vegan Diet and Bone Health - Results from the Cross-Sectional NutriNet-Sante Study",
          "source": "Nutrients",
          "year": 2021,
          "doi": "10.3390/nu13020685",
          "pmid": "33669942",
          "url": "https://doi.org/10.3390/nu13020685"
        }
      ],
      "verified_count": 1
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    {
      "kind": "substance",
      "id": "alicina",
      "name": "Alicina",
      "studies": [
        {
          "title": "Garlic for hypertension: A systematic review and meta-analysis",
          "journal": "BMC Cardiovascular Disorders",
          "year": 2008,
          "doi": "10.1186/1471-2261-8-13",
          "condition": "Hypertension",
          "evidence_level": "High",
          "verified": true
        },
        {
          "title": "Effect of garlic on serum lipids: an updated meta-analysis",
          "journal": "Nutrition Reviews",
          "year": 2013,
          "doi": "10.1111/nure.12012",
          "condition": "Hyperlipidemia",
          "evidence_level": "Medium",
          "verified": true
        }
      ],
      "verified_count": 2
    },
    {
      "kind": "substance",
      "id": "antocianina",
      "name": "Antocianina (Cianidina)",
      "studies": [
        {
          "title": "Effects of Anthocyanins on Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials",
          "journal": "Adv Nutr",
          "year": 2017,
          "doi": "10.3945/an.116.014852",
          "condition": "Inflammation / Metabolic syndrome",
          "evidence_level": "Medium",
          "verified": true
        }
      ],
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    },
    {
      "kind": "substance",
      "id": "apigenina",
      "name": "Apigenina",
      "studies": [
        {
          "title": "Apigenin for Depression and Anxiety: A Systematic Review of Preclinical Studies",
          "journal": "Iran J Pharm Res",
          "year": 2026,
          "doi": "10.5812/ijpr-167153",
          "condition": "Anxiety / Insomnia",
          "evidence_level": "Medium",
          "verified": true
        }
      ],
      "verified_count": 1
    },
    {
      "kind": "substance",
      "id": "cafeina",
      "name": "Cafeína",
      "studies": [
        {
          "title": "Caffeine as an attention enhancer: reviewing existing assumptions",
          "journal": "Psychopharmacology",
          "year": 2012,
          "doi": "10.1007/s00213-012-2917-4",
          "condition": "Fatigue / Alertness",
          "evidence_level": "Medium",
          "verified": true
        }
      ],
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    {
      "kind": "substance",
      "id": "capsaicina",
      "name": "Capsaicina",
      "studies": [
        {
          "title": "Mechanisms and clinical uses of capsaicin",
          "journal": "Eur J Pharmacol",
          "year": 2013,
          "doi": "10.1016/j.ejphar.2013.10.053",
          "condition": "Pain / Neuropathy",
          "evidence_level": "High",
          "verified": true
        },
        {
          "title": "Capsaicinoids and capsinoids. A potential role for weight management? A systematic review of the evidence",
          "journal": "Appetite",
          "year": 2012,
          "doi": "10.1016/j.appet.2012.05.015",
          "condition": "Obesity / Metabolic syndrome",
          "evidence_level": "Medium",
          "verified": true
        },
        {
          "title": "Capsaicin and Related Food Ingredients Reducing Body Fat Through the Activation of TRP and Brown Fat Thermogenesis",
          "journal": "Advances in Food and Nutrition Research",
          "year": 2015,
          "doi": "10.1016/bs.afnr.2015.07.002",
          "condition": "Obesity / Metabolic syndrome",
          "evidence_level": "Medium",
          "verified": true
        },
        {
          "title": "Peppers and their constituents against obesity",
          "journal": "Biologia Futura",
          "year": 2023,
          "doi": "10.1007/s42977-023-00174-3",
          "condition": "Obesity / Metabolic syndrome",
          "evidence_level": "Medium",
          "verified": true
        },
        {
          "title": "Capsaicin camphor and caffeic acid reduce adipogenesis and promote lipolysis with TRPV1 involvement",
          "journal": "Scientific Reports",
          "year": 2025,
          "doi": "10.1038/s41598-025-31073-3",
          "condition": "Obesity / Metabolic syndrome",
          "evidence_level": "Medium",
          "verified": true
        }
      ],
      "verified_count": 5
    },
    {
      "kind": "substance",
      "id": "cinamaldehido",
      "name": "Cinamaldehído",
      "studies": [
        {
          "title": "Cinnamon Intake Lowers Fasting Blood Glucose: Meta-Analysis",
          "journal": "J Med Food",
          "year": 2011,
          "doi": "10.1089/jmf.2010.0180",
          "condition": "Type 2 Diabetes",
          "evidence_level": "Medium",
          "verified": true
        }
      ],
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    {
      "kind": "substance",
      "id": "cuminaldehido",
      "name": "Cuminaldehído",
      "studies": [
        {
          "title": "In vitro influence of spices and spice-active principles on digestive enzymes of rat pancreas and small intestine",
          "journal": "Food / Nahrung",
          "year": 2003,
          "doi": "10.1002/food.200390091",
          "condition": "Dyspepsia / Bloating",
          "evidence_level": "Low",
          "verified": true
        },
        {
          "title": "The effect of Cuminum cyminum on the return of bowel motility after abdominal surgery: a triple-blind randomized clinical trial",
          "journal": "BMC Complement Med Ther",
          "year": 2024,
          "doi": "10.1186/s12906-024-04530-1",
          "condition": "Irritable bowel",
          "evidence_level": "Low",
          "verified": true
        }
      ],
      "verified_count": 2
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    {
      "kind": "substance",
      "id": "curcumina",
      "name": "Curcumina",
      "studies": [
        {
          "title": "The effect of curcumin on cognition in Alzheimer's disease and healthy aging: A systematic review of pre-clinical and clinical studies",
          "journal": "Brain Res",
          "year": 2019,
          "doi": "10.1016/j.brainres.2019.146476",
          "condition": "Alzheimer / Cognitive decline",
          "evidence_level": "Medium",
          "verified": true
        }
      ],
      "verified_count": 1
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    {
      "kind": "substance",
      "id": "dodecenal",
      "name": "Dodecenal",
      "studies": [
        {
          "title": "Antibacterial Activity of Coriander Volatile Compounds against Salmonella choleraesuis",
          "journal": "J Agric Food Chem",
          "year": 2004,
          "doi": "10.1021/jf0354186",
          "condition": "Salmonellosis",
          "evidence_level": "Medium",
          "verified": true
        }
      ],
      "verified_count": 1
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    {
      "kind": "substance",
      "id": "eugenol",
      "name": "Eugenol",
      "studies": [
        {
          "title": "The Anti-inflammatory Effects of Eugenol and Its Derivatives: A Scoping Review of Preclinical Evidence",
          "journal": "Res Mol Med",
          "year": 2025,
          "doi": "10.32598/rmm.13.2.1440.1",
          "condition": "Inflammation",
          "evidence_level": "Medium",
          "verified": true
        }
      ],
      "verified_count": 1
    },
    {
      "kind": "substance",
      "id": "genisteina",
      "name": "Genisteína",
      "studies": [
        {
          "title": "Soy phytoestrogen genistein increases bone mineral density in postmenopausal women",
          "journal": "BMJ",
          "year": 2007,
          "doi": "10.1136/bmj.39287.690475.ad",
          "condition": "Postmenopausal osteoporosis",
          "evidence_level": "Medium",
          "verified": true
        }
      ],
      "verified_count": 1
    },
    {
      "kind": "substance",
      "id": "gingerol",
      "name": "Gingerol",
      "studies": [
        {
          "title": "Efficacy of ginger for nausea and vomiting: a systematic review of randomised trials",
          "journal": "British Journal of Anaesthesia",
          "year": 2000,
          "doi": "10.1093/oxfordjournals.bja.a013442",
          "condition": "Nausea / Motion sickness",
          "evidence_level": "High",
          "verified": true
        },
        {
          "title": "Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [6]-shogaol and [1]-shogaol",
          "journal": "Journal of Ethnopharmacology",
          "year": 2010,
          "doi": "10.1016/j.jep.2009.10.004",
          "condition": "Inflammation",
          "evidence_level": "Medium",
          "verified": true
        }
      ],
      "verified_count": 2
    },
    {
      "kind": "substance",
      "id": "licopeno",
      "name": "Licopeno",
      "studies": [
        {
          "title": "The Role of Tomato Products and Lycopene in the Prevention of Prostate Cancer",
          "journal": "Cancer Epidemiol Biomarkers Prev",
          "year": 2004,
          "doi": "10.1158/1055-9965.340.13.3",
          "condition": "Prostate cancer",
          "evidence_level": "Medium",
          "verified": true
        }
      ],
      "verified_count": 1
    },
    {
      "kind": "substance",
      "id": "mentol",
      "name": "Mentol",
      "studies": [
        {
          "title": "Peppermint oil for the treatment of irritable bowel syndrome: a systematic review and meta-analysis",
          "journal": "J Clin Gastroenterol",
          "year": 2014,
          "doi": "10.1097/mcg.0b013e3182a88357",
          "condition": "IBS pain",
          "evidence_level": "High",
          "verified": true
        }
      ],
      "verified_count": 1
    },
    {
      "kind": "substance",
      "id": "oleocanthal",
      "name": "Oleocanthal",
      "studies": [
        {
          "title": "Ibuprofen-like activity in extra-virgin olive oil",
          "journal": "Nature",
          "year": 2005,
          "doi": "10.1038/437045a",
          "condition": "Alzheimer / Inflammation",
          "evidence_level": "Medium",
          "verified": true
        }
      ],
      "verified_count": 1
    },
    {
      "kind": "substance",
      "id": "piperina",
      "name": "Piperina",
      "studies": [
        {
          "title": "Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers",
          "journal": "Planta Medica",
          "year": 1998,
          "doi": "10.1055/s-2006-957450",
          "condition": "Nutrient malabsorption",
          "evidence_level": "High",
          "verified": true
        },
        {
          "title": "The influence of piperine on the pharmacokinetics of fexofenadine, a P-glycoprotein substrate, in healthy volunteers",
          "journal": "Eur J Clin Pharmacol",
          "year": 2016,
          "doi": "10.1007/s00228-016-2173-3",
          "condition": "Nutrient malabsorption",
          "evidence_level": "High",
          "verified": true
        },
        {
          "title": "Anti-inflammatory Effect of Piperine in Adjuvant-Induced Arthritic Rats",
          "journal": "Inflammation",
          "year": 2012,
          "doi": "10.1007/s10753-012-9448-3",
          "condition": "Inflammation",
          "evidence_level": "Low",
          "verified": true
        }
      ],
      "verified_count": 3
    },
    {
      "kind": "substance",
      "id": "quercetina",
      "name": "Quercetina",
      "studies": [
        {
          "title": "Quercetin and allergic diseases",
          "journal": "Molecules",
          "year": 2016,
          "doi": "10.3390/molecules21050623",
          "condition": "Allergy / Histamine",
          "evidence_level": "Medium",
          "verified": true
        },
        {
          "title": "Quercetin and blood pressure: meta-analysis",
          "journal": "J Am Heart Assoc",
          "year": 2016,
          "doi": "10.1161/JAHA.115.002713",
          "condition": "Hypertension",
          "evidence_level": "Medium",
          "verified": true
        }
      ],
      "verified_count": 2
    },
    {
      "kind": "substance",
      "id": "sulforafano",
      "name": "Sulforafano",
      "studies": [
        {
          "title": "Frugal chemoprevention: targeting Nrf2 with foods rich in sulforaphane",
          "journal": "Seminars in Oncology",
          "year": 2016,
          "doi": "10.1053/j.seminoncol.2015.09.013",
          "condition": "Cancer prevention",
          "evidence_level": "High",
          "verified": true
        }
      ],
      "verified_count": 1
    },
    {
      "kind": "substance",
      "id": "timol",
      "name": "Timol",
      "studies": [
        {
          "title": "Thymol antimicrobial review",
          "journal": "J Appl Microbiol",
          "year": 2012,
          "doi": "10.1111/j.1365-2672.2012.05270.x",
          "condition": "Respiratory infection",
          "evidence_level": "Medium",
          "verified": true
        }
      ],
      "verified_count": 1
    },
    {
      "kind": "substance",
      "id": "zeaxantina",
      "name": "Zeaxantina",
      "studies": [
        {
          "title": "Lutein + Zeaxanthin and Omega-3 Fatty Acids for Age-Related Macular Degeneration",
          "journal": "JAMA",
          "year": 2013,
          "doi": "10.1001/jama.2013.4997",
          "condition": "AMD / Macular degeneration",
          "evidence_level": "High",
          "verified": true
        }
      ],
      "verified_count": 1
    },
    {
      "kind": "vitamin",
      "id": "om3-om3",
      "name": "Omega-3 (EPA/DHA)",
      "studies": [
        {
          "title": "Role of Omega-3 Fatty Acids in Improving Metabolic Dysfunctions",
          "source": "Nutrients",
          "year": 2024,
          "doi": "10.3390/nu16172961",
          "url": "https://doi.org/10.3390/nu16172961"
        }
      ],
      "verified_count": 1
    },
    {
      "kind": "vitamin",
      "id": "a-a",
      "name": "Vitamina A",
      "studies": [
        {
          "title": "Vitamin A supplementation for preventing morbidity and mortality in children",
          "source": "Cochrane Database of Systematic Reviews",
          "year": 2022,
          "doi": "10.1002/14651858.CD008524.pub4",
          "url": "https://doi.org/10.1002/14651858.CD008524.pub4"
        }
      ],
      "verified_count": 1
    },
    {
      "kind": "vitamin",
      "id": "b1-b1",
      "name": "Vitamina B1",
      "studies": [
        {
          "title": "Thiamine deficiency disorders: a clinical perspective",
          "source": "Annals of the New York Academy of Sciences",
          "year": 2020,
          "doi": "10.1111/nyas.14536",
          "pmid": "33305487",
          "url": "https://doi.org/10.1111/nyas.14536"
        }
      ],
      "verified_count": 1
    },
    {
      "kind": "vitamin",
      "id": "b12-b12",
      "name": "Vitamina B12",
      "studies": [
        {
          "title": "Efficacy of different routes of vitamin B12 supplementation for the treatment of vitamin B12 deficiency: a systematic review",
          "source": "Irish Journal of Medical Science",
          "year": 2024,
          "doi": "10.1007/s11845-023-03602-4",
          "pmid": "38231320",
          "url": "https://doi.org/10.1007/s11845-023-03602-4"
        }
      ],
      "verified_count": 1
    },
    {
      "kind": "vitamin",
      "id": "b2-b2",
      "name": "Vitamina B2",
      "studies": [
        {
          "title": "Causes and Clinical Sequelae of Riboflavin Deficiency",
          "source": "Annual Review of Nutrition",
          "year": 2023,
          "doi": "10.1146/annurev-nutr-061121-084407",
          "url": "https://doi.org/10.1146/annurev-nutr-061121-084407"
        }
      ],
      "verified_count": 1
    },
    {
      "kind": "vitamin",
      "id": "b3-b3",
      "name": "Vitamina B3",
      "studies": [
        {
          "title": "Definition of a tolerable upper intake level of niacin: a systematic review",
          "source": "Nutrition Reviews",
          "year": 2017,
          "doi": "10.1093/nutrit/nux011",
          "pmid": "28541582",
          "url": "https://doi.org/10.1093/nutrit/nux011"
        }
      ],
      "verified_count": 1
    },
    {
      "kind": "vitamin",
      "id": "b6-b6",
      "name": "Vitamina B6",
      "studies": [
        {
          "title": "Vitamin B6 in Health and Disease",
          "source": "Nutrients",
          "year": 2021,
          "doi": "10.3390/nu13093229",
          "url": "https://doi.org/10.3390/nu13093229"
        }
      ],
      "verified_count": 1
    },
    {
      "kind": "vitamin",
      "id": "b7-b7",
      "name": "Vitamina B7",
      "studies": [
        {
          "title": "Biotin: From Nutrition to Therapeutics",
          "source": "The Journal of Nutrition",
          "year": 2017,
          "doi": "10.3945/jn.116.238956",
          "url": "https://doi.org/10.3945/jn.116.238956"
        }
      ],
      "verified_count": 1
    },
    {
      "kind": "vitamin",
      "id": "b9-b9",
      "name": "Vitamina B9",
      "studies": [
        {
          "title": "Folic Acid Supplementation to Prevent Neural Tube Defects: US Preventive Services Task Force Recommendation Statement",
          "source": "JAMA",
          "year": 2023,
          "doi": "10.1001/jama.2023.9864",
          "pmid": "37526714",
          "url": "https://doi.org/10.1001/jama.2023.9864"
        }
      ],
      "verified_count": 1
    },
    {
      "kind": "vitamin",
      "id": "c-c",
      "name": "Vitamina C",
      "studies": [
        {
          "title": "Vitamin C reduces the severity of common colds: a meta-analysis of randomized controlled trials",
          "source": "BMC Public Health",
          "year": 2023,
          "doi": "10.1186/s12889-023-17229-8",
          "pmid": "38082300",
          "url": "https://doi.org/10.1186/s12889-023-17229-8"
        }
      ],
      "verified_count": 1
    },
    {
      "kind": "vitamin",
      "id": "d-d",
      "name": "Vitamina D",
      "studies": [
        {
          "title": "Calcium, vitamin D, or combined supplementation to prevent fractures in older adults: systematic review and meta-analysis",
          "source": "BMJ",
          "year": 2026,
          "doi": "10.1136/bmj-2025-088050",
          "pmid": "42161415",
          "url": "https://doi.org/10.1136/bmj-2025-088050"
        }
      ],
      "verified_count": 1
    },
    {
      "kind": "vitamin",
      "id": "e-e",
      "name": "Vitamina E",
      "studies": [
        {
          "title": "Vitamin E Intake and Risk of Prostate Cancer: A Meta-Analysis",
          "source": "Nutrients",
          "year": 2022,
          "doi": "10.3390/nu15010014",
          "pmid": "36615673",
          "url": "https://doi.org/10.3390/nu15010014"
        }
      ],
      "verified_count": 1
    },
    {
      "kind": "vitamin",
      "id": "k1-k1",
      "name": "Vitamina K1",
      "studies": [
        {
          "title": "Vitamin K - sources, physiological role, kinetics, deficiency, detection, therapeutic use",
          "source": "Nutrition Reviews",
          "year": 2021,
          "doi": "10.1093/nutrit/nuab061",
          "pmid": "34472618",
          "url": "https://doi.org/10.1093/nutrit/nuab061"
        }
      ],
      "verified_count": 1
    }
  ]
}